How can I make my Perl program take less memory?

In some cases, using substr() or vec() to simulate arrays can be highly beneficial. For example, an array of a thousand booleans will take at least 20,000 bytes of space, but it can be turned into one 125-byte bit vector for a considerable memory savings. The standard Tie::SubstrHash module can also help for certain types of data structure. If you're working with specialist data structures (matrices, for instance) modules that implement these in C may use less memory than equivalent Perl modules.

Another thing to try is learning whether your Perl was compiled with the system malloc or with Perl's builtin malloc. Whichever one it is, try using the other one and see whether this makes a difference. Information about malloc is in the INSTALL file in the source distribution. You can find out whether you are using perl's malloc by typing perl -V:usemymalloc.